Effects on blood Occasionally: increased number of eosinophils, a decrease in the number of white blood cells. Rare: neutropenia; thrombocytopenia, which may be accompanied by increased bleeding. Very rare: agranulocytosis and the development of severe infections (persistent or recurrent fever, deterioration of health). In some cases: haemolytic anemia; pancytopenia.
Other side effects sometimes: . General winstrol stanozolol weakness (asthenia) Very rare: fever, allergic pneumonitis.
Any antibiotic treatment may cause changes flora (bacteria and fungi), which is normally present in humans. For this reason, it may happen enhanced reproduction of bacteria and fungi that are resistant to antibiotics are used (secondary infection and superinfection), which in rare cases may require additional treatment.
Symptoms of an overdose of the drug Levofloxacin is manifest at the level of the central nervous system (confusion, dizziness, impairment of consciousness and seizures seizures by type epipripadkov). In addition, it can be marked gastrointestinal symptoms (eg, nausea) and erosive lesions of the mucous membranes.
In studies of the supra-therapeutic doses of levofloxacin, it has shown prolongation of the interval .
Treatment should be focused on presenting symptoms. Levofloxacin is not displayed by dialysis (hemodialysis, peritoneal dialysis and continuous peritoneal dialysis). Specific antidote (counteracting agent) does not exist.
Interaction with other drugs
There are reports of pronounced lowering winstrol stanozolol the threshold of convulsive readiness, while the use of quinolones and substances that can, in turn, lower the cerebral seizure threshold. Equally, it also relates to the simultaneous use of quinolones and theophylline, fenbufena or similar to it nonsteroidal antiinflammatory drugs (for the treatment of rheumatic diseases).
The action of levofloxacin, the drug significantly attenuated while the use of sucralfate (means to protect the gastric mucosa). The same thing happens with the simultaneous use of magnesium-aluminum containing antacids or (drugs for the treatment of heartburn and gastralgia), as well as salts of iron (for the treatment of anemia). Levofloxacin should take no less than 2 hours before or 2 hours after the administration of these agents. With calcium carbonate interaction have been identified.
With the simultaneous use of vitamin K antagonists should be monitored for blood coagulation system.
Withdrawal (renal clearance) of levofloxacin slightly slowed down by the action of cimetidine and probenicid. It should be noted that this interaction is almost does not have any clinical significance. However, while the use of drugs such as cimetidine and probenicid blocking certain way of deducing (tubular secretion), treatment with levofloxacin should be performed with caution. This applies primarily to patients with reduced renal function.
Levofloxacin slightly increases the half-life of cyclosporin.
Receiving corticosteroids increase the risk of tendon rupture.
Levofloxacin winstrol stanozolol should not be used to treat children and adolescents because of the probability of destruction of the articular cartilage.
In the treatment of elderly patients should be borne in mind that this group of patients often have impaired renal function (see. Section “Dosing and administration”).
In severe pneumonia caused by pneumococcus, levofloxacin can not provide the optimal therapeutic effect. Hospital infections caused by certain pathogens (P. aeruginosa), may require combination therapy.
During treatment with levofloxacin can develop an attack of convulsions in patients with previous brain damage caused by, for example, stroke or severe injury. Seizure may be increased, and while the application fenbufena similar to him NSAIDs or theophylline (see. “Interactions”).
Despite the fact that the photosensitivity observed in the application of levofloxacin is very rare, in order to avoid its ill advised not subjected unnecessarily to strong sunlight or artificial radiation.
If you suspect pseudomembranous colitis should immediately cancel levofloxacin and start appropriate treatment. In such cases, you can not use drugs that suppress intestinal motility.
Rarely observed when using the drug Levofloxacin tendinitis (especially inflammation of the Achilles tendon) may lead to tendon rupture. Elderly patients are more prone to tendonitis. corticosteroid treatment ( “cortisone preparations”) are likely to increase the risk of tendon rupture. If tendinitis is suspected, immediately discontinue treatment with levofloxacin and start appropriate treatment of the affected tendon, for example, providing him rest state .
Patients with deficiency of glucose-6-phosphate dehydrogenase (an inherited metabolic disease) may respond to fluoroquinolones destruction of red blood cells (hemolysis). Therefore, treatment of these patients should be levofloxacin with great care.
Such side effects Levofloxacin drug like dizziness or numbness, drowsiness and visual disturbances , can impair reactivity and ability to concentrate. It can be winstrol stanozolol a risk in situations where these abilities are of special importance (eg while driving, during maintenance of machines and mechanisms, when working in an unstable position). in particular as it concerns cases of drug interactions with alcohol.