Hepatic and / or renal failure, rash during treatment with fluconazole in patients with superficial fungal infection and stanozolol results invasive / systemic fungal infections, concomitant use of terfenadine and fluconazole at a dose of less than 400 mg / day, simultaneous reception potentially hepatotoxic drugs, alcoholism potentially proaritmogennoe status in patients with multiple risk factors (organic heart disease, electrolyte disturbances, concomitant use of drugs that cause arrhythmias), pregnancy.
Pregnancy and lactation
Use of the drug in pregnant women – is impractical, except for serious or life-threatening forms of fungal infections, where the potential benefits from the use of fluconazole for the mother is much higher than the risk to the fetus. Since fluconazole concentration in breast milk and in the plasma of the same, use the drug during lactation is contraindicated.
Dosing and Administration
Inside, swallowing whole. Adults and children over 15 years (with a body weight over 50 kg) in cryptococcal meningitis and cryptococcal infections at other sites on the first day is usually prescribed 400 mg (8 capsules of 50 mg), and then continue treatment 200 mg (4 capsules of 50 mg) – 400 mg (8 capsules of 50 mg), 1 time per day. The duration of treatment for cryptococcal infections depends on the clinical efficacy, confirmed by mycological examination; cryptococcal meningitis treatment should be at least 6-8 weeks. For the prevention of recurrence of cryptococcal meningitis in patients, after completion of a full course of primary therapy fluconazole administered in a dose of 200 mg (4 capsules of 50 mg) per day for a long period of time. when candidemia, disseminated candidiasis, Candida and other invasive infections in the first day dose was 400 mg (8 capsules of 50 mg), and then – 200 mg (4 capsules of 50 mg) per day.
When insufficient clinical efficacy of the dose can be increased to 400 mg (8 capsules 50 mg) per day. The duration of therapy depends on clinical efficacy. In oropharyngeal candidiasis drug is usually prescribed at 150 mg 1 times / day; Duration of treatment – 7-14 days. If necessary, in patients with a severely reduced immune treatment may be longer. For the prevention of relapse of oropharyngeal candidiasis in patients with AIDS, after the completion of a full course of primary therapy – 150 mg 1 time per week. In atrophic oral candidiasis associated with stanozolol results wearing dentures, – 50 mg 1 time per day for 14 days in combination with local antiseptic drugs for the treatment of the prosthesis. in other localizations candidiasis (except genital candidiasis), such as esophagitis, noninvasive bronchopulmonary defeat candiduria candidiasis of the skin and mucous membranes, etc. .d., the effective dose is usually 150 mg / day when the duration of treatment 14-30 days. vaginal candidiasis fluconazole receive a single oral dose of 150 mg. To reduce the frequency of relapses vaginal candidiasis drug may be used in a dose of 150 mg 1 time per month.
The duration of therapy is determined individually; it varies between 4 and 12 months. Some patients may require more frequent application. When balanitis caused of Candida, fluconazole administered single oral dose of 150 mg per day. For the prevention of candidiasis recommended dose – 50-400 mg 1 time per day, depending on the degree of risk of fungal infection. To prevent candidiasis in patients with cancer the recommended dose of fluconazole is 150-400 mg 1 time / day, depending on the degree of risk of fungal infection. If you have a high risk of generalized infection, eg in patients with severe or long-anticipated persistent neutropenia, the recommended dose – 400 mg / day. Fluconazole is administered a few days before the expected occurrence of neutropenia; after increasing the number of neutrophils over one thousand / ml treatment continued for 7 days. At mycosis of the skin, including tinea pedis, smooth skin, inguinal, and skin candidosisrecommended dose stanozolol results is 150 mg 1 time per week or 50 mg 1 time per day , the dosage regimen depends on the clinical and mycological effect. Duration of therapy in ordinary cases is 2-4 weeks, but with athlete’s foot may require a more prolonged treatment (up to 6 weeks). When pityriasis versicolor – 300 mg (two 150 mg capsules) 1 time per week for 2 weeks, some patients It required a third dose of 300 mg per week, while in some cases it is sufficient single dose of 300-400 mg; alternative treatment is the use of 50 mg 1 time a day for 2-4 weeks. In onychomycosis the recommended dose is 150 mg 1 time per week.