Following intravenous administration of fluconazole penetrates well into almost all tissues and body fluids. Drug concentrations in the kidneys, liquid sweat, the epidermis and dermis, synovial fluid, saliva, sputum, lung, peritoneal fluid, vaginal secretions and tissues of the vagina, breast milk similar to its plasma levels.Patients with fungal meningitis fluconazole content in cerebrospinal fluid reaches 80% of the respective levels in the plasma.
The plasma concentrations are directly proportional to the dose. When stanozolol for sale administered in therapeutic doses (200 mg / day in adults), the equilibrium concentration in serum reached the 4-5 day; when used in the first treatment day dose, twice the usual daily, equilibrium concentrations are set to 2-3 day. Apparent volume of distribution is close to the total volume of water in the body. The degree of binding with blood proteins fluconazole does not exceed 11-12%.
Fluconazole is derived mainly kidneys (80% – unchanged, 11% – in the form of metabolites). The half-life – long (30 hours). Fluconazole clearance is dependent on renal function and is directly proportional to creatinine clearance. After dialysis for 3 fluconazole hourly concentration in plasma decreased by 50%.
Cryptococcosis: cryptococcal meningitis, cryptococcal sepsis, cryptococcal infection of the lungs and skin,
systematic and generalized candidiasis: visceral candidiasis with the defeat of the endocardium, abdominal organs, respiratory system, eyes, organs, urinary and genital systems, candidemia,
disseminated candidiasis of the mucous membranes: the mouth, nose, throat, esophagus, non-invasive bronchopulmonary infections, candiduria;
vaginal candidiasis (acute or chronic recurrent form); deep endemic mycoses (histoplasmosis, coccidioidomycosis, sporotrichosis) in patients with normal immunity,
prevention of systemic fungal infections (primarily candidiasis) in patients undergoing bone marrow transplantation who receive cytotoxic therapy, patients with malignant tumors, on the background of chemotherapy and radiation therapy; Prevention of relapse of oropharyngeal candidiasis in patients.
Hypersensitivity to fluconazole and other drugs from the group of azoles; pregnancy; lactation. Concomitant use is contraindicated stanozolol for sale with terfenadine or astemizole .
hepatic insufficiency, rash during treatment with fluconazole in patients with superficial fungal infection and invasive / systemic fungal infections, concomitant use of terfenadine and fluconazole at a dose of less than 400 mg / day, potentially proaritmogennoe status in patients with multiple risk factors of patients (organic heart disease , electrolyte disturbances, concomitant use of drugs that cause arrhythmias), pregnancy.
Pregnancy and lactation
The use of fluconazole during pregnancy is indicated only in severe generalized and potentially life-threatening fungal infections. If necessary, the appointment during lactation should stop breastfeeding.
Dosing and Administration
The doses and dosing regimens depend on nosology. Adults For the treatment of systemic candidiasis, including visceral candidiasis, disseminated candidiasis, Candida pneumonia, chronic generalized (granulomatous) candidiasis, Candida peritonitis, candidemia loading – 400 mg on the first day of therapy, then – 200 mg per day. When insufficient clinical efficacy of the dose can be increased to 400 mg / day. . The duration of therapy depends on clinical efficacy for the treatment of cryptococcosis of various localization loading on the first day of therapy is 400 mg; on subsequent days 200 mg once a day, in low clinical efficacy – 400 mg once a day. Duration of therapy cryptococcal meningitis is not less than 8 weeks, until obtaining a negative. For the prevention of relapse of cryptococcal meningitis in patients after completion of a full course of primary treatment stanozolol for sale administered at a dose of 200 mg / day for a long period of time. In deep endemic mycoses: histoplasmosis, coccidioidomycosis, sporotrichosis loading on the first day of therapy is 400 mg ; on subsequent days 200 mg once a day. The duration of therapy is determined individually; it can be 11-24 months. with coccidioidomycosis; 2-17 months. when paracoccidioidomycosis; 1-16 months. with sporotrichosis; 3-17 months. with histoplasmosis; Considering the need to long-term use of fluconazole at these infections (up to 2 years), preferably step therapy. For the prevention of candidiasis are immunocompromised, including patients in need of bone marrow transplants, the recommended is 50-400 mg 1 time / day, depending on the degree of risk of fungal infection. If you have a high risk of generalized infection, eg in patients with severe or long-anticipated persistent neutropenia, the recommended dose is 400 mg 1 time / day. Is prescribed for a few days before the expected occurrence of neutropenia; after increasing the number of neutrophils , treatment was continued for 7 days. Children aged 1 month. up to 12 years accepted the following relationship dosages stanozolol for sale® in children and adults:
In children, as well as with similar infections in adults, the duration of treatment depends on the clinical and mycological effect. The drug is administered in the form of in / infusion of 1 times / days (see method of administration.); daily dose should not exceed 600 mg / day.