If further provides a transplant of hematopoietic stem cells, caution must be exercised in the appointment of fludarabine, which relates to cytotoxic agents.
When non-irradiated blood transfusion patients treated with fludarabine, observed the development of the reaction “graft versus host” (reaction transfuziruemyh immunocompetent lymphocytes versus-host disease), which is associated with a high incidence of deaths. Patients buy stanozolol who need blood transfusions and receiving or receiving fludarabine, only irradiated blood to be transfused.
decay syndrome tumors arising in the treatment fludarabine observed in patients with large tumor mass. Since fludarabine can have a therapeutic effect at the first week of therapy, it is necessary to take precautions in patients with probable risk of developing this complication.
Regardless of the presence or absence of a history of autoimmune processes, and also from Coombs tests results there is a risk of life-threatening autoimmune reactions (autoimmune hemolytic anemia, autoimmune thrombocytopenia, thrombocytopenic purpura, pemphigus, Evans’ syndrome) buy stanozolol during or after treatment with fludarabine. Possible re-hemolytic process after the resumption of treatment with fludarabine. Patients receiving fludarabine should be closely monitored for hemolysis detection. With the development of hemolysis recommended termination of therapy. The most commonly used therapeutic measures for the treatment of autoimmune hemolytic anemia – Blood transfusion (irradiated) and glucocorticosteroids.
Men and women, sexually active should use reliable methods of contraception during (and for 6 months after) treatment with fludarabine.
During and after treatment with fludarabine should avoid vaccination with live vaccines.
Most patients are not sensitive to fludarabine are also insensitive to chlorambucil.
Use only transparent and colorless solution, free of visible particulates. In case of damage do not use the drug container.
The chemical and physical stability of the solution prepared for injection or infusion, maintained for 3 days at a temperature of 25 ° C or in the refrigerator (2-8 ° C) when diluted concentrate solution or 0.9% sodium chloride 5% dextrose solution for infusion for infusions. From the point of view of microbiological purity dilute solution should be used immediately, the diluted solution be stored in the refrigerator (2-8 ° C) for up to 24 hours.
When working with fludarabine should follow the rules of treatment with cytotoxic drugs. Avoid contact with the solution! After contact with skin, mucous membranes or eyes, wash thoroughly with plenty of water.
Effects on ability to drive a car and to management of mechanisms
Some side effects of drugs, such as buy stanozolol increased fatigue, weakness, blurred vision, may adversely affect the ability to drive and engage in potentially hazardous activities that require high concentration and psychomotor speed reactions.