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8125

stanozolol dosage

After oral administration fluconazole is well absorbed, bioavailability – 90%. The maximum concentration after oral administration of the drug on an empty stomach 150 mg sostavlyaet90% of plasma concentration after intravenous injection in a dose of 2.5-3.5 mg / l. Simultaneous food intake does not affect the absorption of fluconazole, taken orally.The time to maximum concentration after oral administration of 150 mg of the drug on an empty stomach – 0.5-1.5 hours. Plasma stanozolol dosage concentration is in direct proportion to the dose. The level of 90% of the equilibrium concentration is achieved in 4-5 day drug treatment (at reception 1 times / day). The introduction of “shock” dose (the first day), 2 times the usual daily dose, achieves a concentration level that corresponds to 90% of the equilibrium concentration of the second day. The volume of distribution close to the total water content in the body. Contact with blood plasma proteins – 11-12%. Fluconazole penetrates well into all body fluids. The concentration of active substance in breast milk, synovial fluid, saliva, sputum, and peritoneal fluids are similar to that of the plasma. Fixed values attained in vaginal secretions after 8 hours after oral administration and are maintained at this level for at least 24 hours. Fluconazole well penetrates into cerebrospinal fluid  in fungal meningitis concentration  is about 80% of its level in plasma. In the sweat fluid, the epidermis and stratum corneum (selective accumulation) in concentrations exceeding serum. On day 7 after ingestion of 150 mg fluconazole concentration in the stratum corneum is 23.4 g / g after 1 week after the second dose – 7.1 g / g. Concentration of fluconazole in healthy nails after 4 months of treatment at a dose of 150 mg 1 time per week was 4.05 g / g and 1.8 mg / g – in the affected nails. It is an inhibitor of CYP2C9 isoenzymes in the liver. Stanozolol dosage is detected in the peripheral blood.Report mostly kidneys (80% – unchanged, 11% – in the form of metabolites). The half-life of fluconazole -. About 30 hours clearance of fluconazole is proportional to the creatinine clearance. After dialysis for 3 hr in the plasma concentration of fluconazole is reduced by 50%.

Indications

  • cryptococcosis, including cryptococcal meningitis and other localization of the infection (including lung, skin), in patients with a normal immune response, and patients with various forms of immunosuppression ( patients, organ transplant ); drug can be used to prevent cryptococcal infection in  patients;
  • mucosal candidiasis, including oral cavity and pharynx (including atrophic oral candidiasis associated with wearing dentures), esophageal, non-invasive bronchopulmonary candidiasis, candiduria;Prevention of relapse of oropharyngeal kandidozau ;
  • genitalny candidiasis: vaginal candidiasis (acute and chronic recurrent); prophylactic use to reduce the frequency of relapses of vaginal candidiasis (3 or more episodes per year); Candida balanitis;
  • generalized candidiasis including candidemia, disseminated candidiasis and other forms of invasive Candida infections (infections of the peritoneum, endocardium, eyes, respiratory and urinary tract). The treatment can be carried out in patients with cancer, patients in intensive care units, patients undergoing a course of cytostatic or immunosuppressive therapy, as well as the presence of other factors predisposing to the development of candidiasis;
  • fungal infections of the skin, including tinea pedis, body, groin; pityriasis (multicolored) versicolor, onychomycosis and skin candida infection;
  • deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immune systems;
  • prevention of fungal infections in patients stanozolol dosage with malignancy who are predisposed to such infections as a result of chemotherapy, cytostatics or radiation therapy.

Contraindications

  • Hypersensitivity to fluconazole, other azole drug components or compounds with a similar structure of fluconazole;
  • concomitant use of terfenadine (on the background of continuous use of fluconazole 400 mg / day or more);
  • concomitant use of cisapride, astemizole, as well as other drugs prolonging the stanozolol dosageinterval;
  • lactation;
  • Children under 4 years of age.
8127

stanozolol side effects

Fluconazole potentiated the effect of coumarin anticoagulants may increase in prothrombin time. It promotes the prolongation of the prothrombin time in patients receiving warfarin. Appointing fluconazole in combination with anticoagulants, it is necessary to monitor the prothrombin index.
When concomitantly with fluconazole increased concentration of sulfonylureas – chlorpropamide, glibenclamide, glipizide and tolbutamide, which potentiates the risk of uncontrolled hypoglycemia. It is stanozolol side effects necessary to periodically monitor blood glucose levels and, if necessary, correct the dose of hypoglycemic agents (risk of hypoglycaemia!). Thiazide diuretics : may increase the level of fluconazole in plasma. Phenytoin : concomitant use with fluconazole results in an increase of phenytoin plasma concentrations at clinically relevant degree ( the combined use is necessary monitorirovnie phenytoin plasma concentrations). Rifampicin reduces the following pharmacokinetic parameters of fluconazole a more rapid elimination of fluconazole from plasma (20%) requires an increase in the dose. Cyclosporine A : while receiving fluconazole may increase the concentration of cyclosporine, which requires monitoring of its concentration, control over the performance of the plasma creatinine and dose adjustment.

Theophylline : while receiving with fluconazole may increase theophylline concentration in the blood by increasing its half-life (the risk of intoxication). Requires dynamic clinical monitoring and monitoring of theophylline with a possible correction dosage concentrations. Terfenadine, and cisapride : while receiving fluconazole possible increase in their concentration in the plasma, which is accompanied by a prolongation of the QT interval and potentiates the risk of ventricular arrhythmias including paroxysmal ventricular tachycardia (torsades de . pointes) zidovudine : while receiving fluconazole may increase zidovudine plasma concentrations. rifabutin : when taken with fluconazole may increase the levels of rifabutin plasma, in some cases – the development of uveitis. astemizole : simultaneous reception of astemizole and fluconazole, drugs, metabolism involving a system of enzymes of the cytochrome thestanozolol side effects, can be accompanied by an increase in their concentration in plasma.Tacrolimus : while receiving fluconazole increased risk of nephrotoxicity. at the same time taking fluconazole increases plasma concentration of benzodiazepine short-acting , which in some cases require correction of their doses. The solution  for intravenous administration is compatible with 0.9% sodium chloride solution, 5-10% dextrose, Ringer’s solution, potassium chloride solution in glucose solution Hartmann. in view of the likely pharmacological incompatibility does not add or mix Flukomabola solution ® with other drugs ! When assigning the patient a few drugs administered in / in, observe the sequence of administration, or administered Flukomabol ® through separate intravenous catheter or a system / in infusions.

 

Specific guidance
Treatment should be continued until clinical, and immunocompromised patients – also remission. Premature discontinuation of treatment leads to relapse. During treatment it is necessary to monitor blood counts, kidney and liver. In the event of severe impaired renal and hepatic function should stop taking the drug. Hepatotoxic action of Fluconazole is usually reversible, symptoms disappear after cessation of therapy. In the event of skin rash in patients with immunosuppression should be carefully monitored, and if the progression of skin reactions treatment should be discontinued (risk of the syndrome of Stevens-Johnson syndrome, Lyell’s syndrome). Requires monitoring prothrombin index while the use of coumarin anticoagulants. It is recommended to carry out dynamic monitoring of cyclosporine concentrations in the blood in patients after organ transplantation, while receiving  , as administration of fluconazole 200 mg / day leads to a slow increase in the concentration of cyclosporine, which can lead to toxic effects.
Taking certain azoles, including fluconazole, can be accompanied by a prolongation of the QT interval, so the appointment  in patients at risk of arrhythmias, especially heavy patients, who have organic lesion of the myocardium and the pathways of the heart, electrolyte imbalance and / or receiving supportive kardiotropnyh therapy should be strictly justified and carried out under close medical supervision and monitoring of ECG.
parenteral stanozolol side effects in preterm infants should be undertaken under close medical supervision.
Given dysfunction kidney in elderly (> 65 years) patients, the choice of dose and administration regimen is recommended to take into account the biochemical tests that characterize the function of the kidneys, as well as to conduct their dynamic monitoring.

stanozolol tablets

For the treatment of systemic candidiasis (candidemia, visceral candidiasis chronic generalized (granulomatous) candidiasis) loading dose on day 1 of treatment is 12 mg / kg / day on subsequent days is administered at stanozolol tablets.
in cryptococcal infection, including cryptococcal meningitis, loading dose on day 1 of treatment is 12 mg / kg / day, administered in the following days at the rate of 6 mg / kg / day. Depending on the clinical response, the dose may be increased to 12 mg / kg / day. Duration of therapy -. 8-12 weeks
Patients with severe oropharyngeal candidiasis, Candida esophagitis, and the impossibility of oral fluconazole forms administered at the rate of 6 mg / kg – in the first day of therapy in the following days, 3 mg / kg / day.

Duration of treatment for oropharyngeal candidiasis – 2 weeks; When Candida esophagitis -. 3 weeks, continue taking fluconazole another 2 weeks after the relief of symptoms of infection
, for which the risk of infection development associated with the induced neutropenia (patients undergoing bone marrow transplantation for treatment with cytostatic and radiation therapy of malignant For the prevention of fungal infections in children neoplasms) dosestanozolol tablets is 3-12 mg / kg / day, depending on the severity and duration of neutropenia save. . Required to monitor patterns of peripheral blood of newborns under the age of 4 weeks  is used in the same doses as in older children, but increase the interval between administration of the drug: from 0 to 2 weeks of age are administered every 72 hours, with 2 4 weeks of life – every 48 hours.

The method of administration
Administered intravenously at a slow infusion mode; infusion rate – 200 mg (1 bottle) per hour. Do not use solution as an infusion environment for the introduction of other drugs.

Side-Effects
Fluconazole is generally well tolerated. It is noted that the frequency of adverse drug reactions significantly higher in the population of patients . From the nervous system : headache, dizziness, convulsions. On stanozolol tablets the part of the gastrointestinal tract : changes in taste, nausea, vomiting, diarrhea, flatulence, abdominal pain, dysfunction liver (increased levels of alkaline phosphatase, bilirubin, serum levels of transaminases, hepatitis, hepatocellular necrosis, including fatalities). since the cardiovascular system : prolongation of the interval, flicker / ventricular flutter. from the side of hematopoiesis : thrombocytopenia, leukopenia, neutropenia, agranulocytosis. From the urinary system : renal failure. Allergic reactions : skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactoid reactions. Other : renal failure, alopecia, hypercholesterolemia, hypertriglyceridemia, hypokalemia.

 

Overdose Symptoms : transient mental disorders stanozolol tablets – hallucinations, psychosis-reaction (paronoidalnoe behavior); . neurological disorders – ptosis, lacrimation, salivation, disturbances of the dynamics, convulsions, spontaneous urination, dyspnea Treatment : In acute poisoning shows hemodialysis; 3-hour hemodialysis procedure can be reduced serum concentrations of fluconazole by 50%.